The Alphabet Killer is based on the double initial killings in Rochester, New York in the early 1970s. Eliza Dusku stars as Megan Paige, a police officer who is highly committed to the job. She develops schizophrenia, lasting for more than six months, and includes one month of active symptoms such as illusions, hallucinations, disorganized speech, and grossly disorganized or catatonic behavior. Megan's obsession leads her to a breakdown and a violent episode which lands her in the hospital. She eventually loses her fiance, Kenneth (Cary), and her job. Two years later Megan is back working as an advisor, but her more or less normal life goes to hell again when another murder is called in. Her fire rekindled, Megan sets out to find the killer, and this time she plans to get the job done, with or without the department's assistance.